本文介绍了近年来对耐药性恶性滋养细胞肿瘤病人诊治的最新进展。从理论上探讨了耐药细胞株的来源,促使耐药产生的因素及判断耐药的标准。总结了近年来国外文献所报道的十种化疗方案,各方案的主要副作用。并对如何防止化疗反应,防止耐药发生进行介绍。 This article describes the recent progress in the diagnosis and treatment of drug resistant malignant trophoblastic tumors. In theory, we explored the origin of drug-resistant cell lines, the factors that led to drug resistance, and the criteria for judging drug resistance. Summarizes the ten chemotherapy regimens reported in foreign literature in recent years, the main side effects of various programs. And how to prevent the response to chemotherapy to prevent the occurrence of resistance introduced.