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分析了370例肺癌先证者的核心家系和370个对照的核心家系资料,发现肺癌先证者的亲属(父母、同胞)患癌症的危险性明显高于对照的亲属(父母、同胞),前乾是后者的2.07倍(P〈0.01)。其中患癌的危险性是对照亲属的1.85倍,患其它癌症的危险性是3.78倍,差别均具有高度显著性统计学意义,表明了宣威肺癌患者的亲属不仅对肺癌的易感性增高,而且对其它癌症的易感性也较高。这些结果都支持了肺癌患者的家系亲属对癌症具有遗传易感性的假设。
The data of 370 core families of lung cancer probands and 370 control core families were analyzed. It was found that relatives (parents, siblings) of lung cancer probands were significantly more likely to have cancer than their relatives (parents, siblings). The dryness was 2.07 times that of the latter (P<0.01). The risk of cancer was 1.85 times that of the control relatives and the risk of other cancers was 3.78 times. The difference was highly statistically significant, indicating that the relatives of Xuanwei lung cancer patients were not only susceptible to lung cancer. Perceptual increase, but also higher susceptibility to other cancers. These results support the hypothesis that family members of lung cancer patients have genetic susceptibility to cancer.