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目的 :探讨舒筋灵、唛酚生、地西泮三种中枢性肌松剂对杀虫单 (SCD)急性中毒的解救效果。方法 :采用 Bliss法测定 L D5 0 ,并进行其显著性测定。结果 :三种肌松剂能提高小鼠 SCD急性中毒 L D5 0 3～ 4倍 ,差异非常显著 ,二疏基丙磺酸钠 (DMPS)与肌松剂合用效果更佳。先给中枢性肌松剂对大鼠 SCD急性中毒有良好的保护作用。结论 :SCD经口染毒主要是引起中枢性兴奋致惊厥最后衰竭而死。单用中枢性肌松剂有良好的拮抗作用 ,如合用 DMPS效果更佳
Objective: To investigate the rescue effects of Shu Jinling, Mark Phenolsheng and diazepam on acute poisoning of single insecticidal single (SCD). Methods: L D50 was determined by Bliss method and its significance was determined. Results: Three kinds of muscle relaxants can improve mice acute SCD acute poisoning L D5 0 ~ 4 times, the difference is very significant, and the combination of sodium dithiosulfate (DMPS) and muscle relaxants better. First give the central muscle relaxants SCD acute poisoning rats have a good protective effect. Conclusion: SCD oral exposure is mainly caused by central excitability convulsions eventually died. Monotherapy with central muscle relaxants have a good antagonistic effect, such as combined DMPS better