论文部分内容阅读
目的:分析余杭区第三人民医院地高辛血药浓度监测结果,为临床安全、有效、合理使用地高辛提供参考。方法:选择服用地高辛超过5个半衰期的患者168例,采用化学发光免疫分析(CLIA)法测定地高辛血药浓度,并对所监测的结果结合临床资料进行统计学分析。结果:在168例患者中,血药浓度<0.5μg.L~(-1)的有30例(17.9%),没有出现中毒症状者;在0.5~1.75μg.L~(-1)的有116例(69.0%),出现中毒症状的有4例(3.5%);>1.75μg.L~(-1)的有42例(13.1%),出现中毒症状的有14例(63.6%)。且不同年龄组地高辛血药浓度差异有显著性。结论:地高辛血药浓度受患者年龄、性别等因素影响。加强地高辛血药浓度监测,制定个体化给药方案,对确保地高辛临床疗效,减少不良反应的发生,具有重要意义。
OBJECTIVE: To analyze the results of digoxin concentration monitoring in Third People’s Hospital of Yuhang District for reference for safe, effective and rational use of digoxin. Methods: 168 patients who took digoxin more than 5 half-lives were selected. The plasma concentration of digoxin was determined by chemiluminescence immunoassay (CLIA), and the results were combined with clinical data for statistical analysis. Results: Of the 168 patients, there were 30 (17.9%) patients with no blood poisoning at a concentration of 0.5μg.L -1 and 0.5 ~ 1.75μg.L -1 116 cases (69.0%), 4 cases (3.5%) with symptoms of poisoning, 42 cases (13.1%) with> 1.75μg.L -1 and 14 cases (63.6%) with symptom of poisoning. And different age groups digoxin plasma concentration difference was significant. Conclusion: The plasma concentration of digoxin is affected by the age and gender of the patient. To strengthen the monitoring of digoxin blood concentration, to develop individualized dosing regimen, to ensure the clinical efficacy of digoxin and reduce the occurrence of adverse reactions, is of great significance.