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目的 评价甲磺酸加替沙星片治疗急性细菌性感染疾病的细菌学疗效。方法 以盐酸左氧氟沙星片为对照药 ,采用多中心随机盲法阳性对照平行试验设计方法 ,评价甲磺酸加替沙星片治疗急性细菌性感染的细菌学疗效。结果 甲磺酸加替沙星片组和盐酸左氧氟沙星片组细菌分离阳性率分别为 77 4 2 %和 80 99% ;两组细菌清除率分别为 97 92 %和 97 96 % ;对不同致病菌感染有效率分别为 83 33%～ 10 0 %和 80 %～ 10 0 % ;以上结果两组差异无统计学意义 ;纸片药敏试验结果表明加替沙星、左氧氟沙星、氧氟沙星、环丙沙星和司帕沙星的细菌敏感率分别为 93 81%、93 30 %、91 2 4 %、84 5 4 %和 87 11% ;从MIC90 结果看 ,加替沙星对多数致病菌的抗菌活性略强于左氧氟沙星。结论 甲磺酸加替沙星片具有良好的细菌学疗效。
Objective To evaluate the bacteriological efficacy of gatifloxacin mesylate in the treatment of acute bacterial infections. Methods The levofloxacin hydrochloride tablets as the control drug were used to evaluate the bacteriological efficacy of gatifloxacin mesylate tablets in the treatment of acute bacterial infections by a parallel multicenter blind randomized controlled trial. Results The positive rates of bacterial isolation of gatifloxacin mesylate tablets and levofloxacin hydrochloride tablets group were 77 4 2% and 80 99%, respectively. The bacterial clearance rates of the two groups were 97 92% and 97 96%, respectively. The effective rates of infection were 83 33% ~ 100% and 80% ~ 100% respectively. There was no significant difference between the two groups in the above results. The susceptibility test results showed that gatifloxacin, levofloxacin, ofloxacin, The bacterial susceptibilities of ciprofloxacin and sparfloxacin were 93 81%, 93 30%, 91 2 4%, 84 5 4% and 87 11%, respectively. From MIC90 results, The antibacterial activity slightly stronger than levofloxacin. Conclusion Gatifloxacin mesylate tablets have good bacteriological efficacy.