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目的了解新生儿重症监护室侵袭性真菌的感染情况及其危险因素,提出应对措施。方法通过回顾性调查,对某医院新生儿重症监护室(NICU)住院新生儿真菌感染情况进行了调查与分析。结果共调查该医院NICU住院新生儿1 146例,发生侵袭性真菌感染66例,感染率为5.76%。新生儿胎龄、出生体重、窒息、机械通气、使用广谱抗生素和静脉插管留置等因素与侵袭性真菌感染关系密切。Logistic回归分析结果支持出生体重、机械通气、使用广谱抗生素和静脉插管等因素为新生儿侵袭性真菌感染的独立危险因素。结论新生儿侵袭性真菌感染率较高,出生体重、机械通气、静脉插管和使用广谱抗菌药物等因素为感染的独立诱发因素。
Objective To understand the infection status and risk factors of invasive fungi in neonatal intensive care unit and to provide countermeasures. Methods A retrospective survey was conducted to investigate the prevalence of neonatal fungal infections in hospital neonatal intensive care unit (NICU). Results A total of 1 146 neonates were hospitalized in NICU of the hospital. 66 cases of invasive fungal infection occurred, with an infection rate of 5.76%. Neonatal gestational age, birth weight, asphyxia, mechanical ventilation, the use of broad-spectrum antibiotics and intravenous catheter indwelling factors such as invasive fungal infection are closely related. Logistic regression analysis supported independent factors such as birth weight, mechanical ventilation, the use of broad-spectrum antibiotics and venous cannulation as invasive neonatal invasive fungal infections. Conclusion Neonatal invasive fungal infection rate, birth weight, mechanical ventilation, intravenous catheterization and the use of broad-spectrum antimicrobial agents and other factors for the independent predisposing factors.