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目的探讨帕金森病患者轻度认知功能障碍(PD-MCI)的临床特点。方法纳入85例非痴呆的帕金森病(PD)患者,并进行临床资料的采集及相关量表评估。结果 PD-MCI组55例(64.7%),PD-认知正常组30例(35.3%)。PD-MCI组的年龄及发病时年龄显著高于PD-认知正常组(P<0.05),PD-MCI组MoCA评分中的视空间与执行功能、注意、语言、抽象、延迟回忆得分显著低于PD-认知正常组(P<0.01)。PD-MCI组的MoCA评分与UPDRSⅢ评分及发病年龄呈负相关,与受教育水平呈正相关。结论与认知功能正常的PD患者比较,PD-MCI患者在视空间与执行功能、注意、语言、抽象、延迟回忆等方面均有损害,且认知损害程度与发病年龄、运动症状严重程度及受教育水平有关。
Objective To investigate the clinical features of mild cognitive impairment (PD-MCI) in patients with Parkinson’s disease. Methods Eighty - five patients with Parkinson ’s disease (PD) without dementia were enrolled in this study. Clinical data collection and related assessment were performed. Results 55 cases (64.7%) in PD-MCI group and 30 cases (35.3%) in PD-cognitive group. The age and onset age of PD-MCI group were significantly higher than those of PD-cognitive group (P <0.05). The scores of visual spatial and executive function, attention, language, abstraction and delayed recall in MoCA score of PD-MCI group were significantly lower In PD-cognitive normal group (P <0.01). MoCA score in PD-MCI group was negatively correlated with UPDRS III score and age of onset, and was positively correlated with education level. Conclusions Compared with PD patients with normal cognitive function, patients with PD-MCI have impairment in visual space and executive function, attention, language, abstraction and delayed recall, and the degree of cognitive impairment and age of onset, severity of motor symptoms and By education level.