去纤苷是单链脱氧寡核苷酸混合物衍生的生化药,主要作用于内皮细胞并产生多种生物学效应,临床研究主要是围绕心血管功能紊乱的适应症来开展的。临床实验证实去纤苷可以有效预防及治疗肝小静脉闭塞症。最近,在一些动物实验中,去纤苷表现出了抗肿瘤及抗血管新生的活性。相关的研究一直在深入开展。 Defibrotide is a biochemical drug derived from a mixture of single-stranded deoxynucleosides, which acts mainly on endothelial cells and produces a variety of biological effects. Clinical studies have mainly focused on indications of cardiovascular dysfunction. Clinical experiments confirmed that defibrotide can effectively prevent and treat hepatic vein occlusive disease. Recently, defibrinated glycosides show antitumor and antiangiogenic activity in some animal experiments. Related research has been carried out in depth.