“现在的药品疗效越来越差了”,这是近几年临床上反映比较多的问题之一。笔者认为,除了药品质量这一主要和重要的原因之外,还有以下几个不可忽视的因素。 1,细菌的耐药性与机体的耐受性增大。近几年,临床上普遍存在着抗生素的不合理使用,并且使用的档次越来越高。抗生素的不合理使用使病原微生物的耐药性也越来越强,致使一些基本的抗生素如青霉素G.氨苄青霉素等疗效越来越差。同时,当患者反复 “Now the drug treatment is getting worse,” which is one of the more clinically reflected problems in recent years. In my opinion, in addition to the main and important reasons for the quality of medicines, there are several factors that can not be ignored. 1, the bacterial resistance and the body’s tolerance increased. In recent years, the prevalence of clinical use of antibiotics unreasonable, and the use of higher and higher grade. The unreasonable use of antibiotics makes the resistance of pathogenic microorganisms more and more strong, resulting in some basic antibiotics such as penicillin, ampicillin and other curative effects getting worse. At the same time, when the patient repeatedly