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目的观察并探讨同期放化疗治疗中晚期鼻咽癌(Ⅲ或Ⅳ期)的疗效。方法对81例鼻咽癌(NPC)患者的放化疗综合治疗进行回顾性分析。结果采用影像学手段对肿瘤大小进行跟踪,放疗后复查评价疗效,放、化疗治疗结束时颈部淋巴结退缩情况:全部消失33例;退缩>50%35例;退缩<50%9例,无变化4例,其中无变化4例均是做过颈部穿刺或淋巴结切取活检,总有效率CR68/81(84%),原发灶退缩情况CR72/81(89%),PR者7/81(9%)。结论鼻咽癌进行放疗时结合化疗,可增强放疗的敏感性,可防止或消除微小转移病灶,消除复发根源,减少转移机会。
Objective To observe and discuss the effect of concurrent chemoradiotherapy on advanced nasopharyngeal carcinoma (stage Ⅲ or Ⅳ). Methods A total of 81 patients with nasopharyngeal carcinoma (NPC) treated with radiotherapy and chemotherapy were retrospectively analyzed. Results The size of the tumor was followed up by radiological method. The curative effect was evaluated after radiotherapy. The cervical lymph node regression at the end of radiotherapy and chemotherapy was completely disappeared in 33 cases, with a reduction of 50% in 35 cases and in 50% in 9 cases with no change 4 cases of which no change in 4 cases were done cervical puncture or lymph node biopsy, the total effective rate CR68 / 81 (84%), the primary lesion CR72 / 81 (89%), PR 7/81 9%). Conclusions Radiotherapy with nasopharyngeal carcinoma combined with chemotherapy can enhance the sensitivity of radiotherapy to prevent or eliminate micro-metastatic lesions, eliminate the root causes of recurrence and reduce the chance of metastasis.