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离体人血细胞受γ射线照射后,用标记的伴刀豆球蛋白(~3H-ConA)检查细胞质膜上与其相结合的受体含量变化。结果表明:受0.25—4Gy照射后,血小板、淋巴细胞与红细胞显示出不同的辐射敏感性,这种膜功能变化具有明显的一过性恃点。本文认为:辐射引起的细胞膜上与ConA结合受体的增加,其原因是由于膜的超分子构象发生变化,从而造成膜表面受体重排的结果。对于应用膜探针作为辐射生物剂量计的实际意义,文章也进行了初步讨论。
After isolated human blood cells were irradiated with gamma rays, the labeled receptor concanavalin (~3H-ConA) was used to examine the changes in the receptor binding to the plasma membrane. The results showed that platelets, lymphocytes, and red blood cells showed different radiation sensitivities after exposure to 0.25-4 Gy, and this membrane function has obvious transient defects. This article believes that the increase in conjugation of receptors on the cell membrane with ConA is due to changes in the supramolecular conformation of the membrane, resulting in the rearrangement of receptors on the membrane surface. For the practical significance of using membrane probes as radiation biodosimeters, the article also conducted a preliminary discussion.