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中国水仙(Narcssus tazetta L var chin—enslsRoem)的总生物碱对动物肿瘤具有明显的抑制作用,前曾报道从中分到石蒜碱、多花水仙碱、雨石蒜碱、高石蒜碱、石蒜宁和假石蒜碱。我们在对抗癌成分进行追踪分离中得到盐酸漳州水仙碱,在7mg/kg 和35mg/kg剂量,分别对大鼠金生瘤和小鼠肉瘤-180的抑制率为49～75%和41～64%。为供药理及临床观察用药,几年来我们进行了多批中间试制,找到由总生物碱直接制备盐酸漳州水仙碱的简便工艺方法。流程见附表,产率约0.03%。从生物碱母液中得到加兰他敏和网球花定(haemanthidine)。在乙醇提取物中得到β-谷甾醇。
The total alkaloids of Narcissus tazetta L var chin-ensls Roem have a significant inhibitory effect on animal tumors. It was previously reported that from the middle to the lycopene, multi-flower narcissus, lyophylline, lyophylline, lycopene Ning and fake Lycorine. We obtained cinxine hydrochloride in the chase and separation of anti-cancer components. At the doses of 7 mg/kg and 35 mg/kg, the inhibition rates of rat gold tumor and mouse sarcoma 180 were 49 to 75% and 41 to 49, respectively. 64%. For pharmacological and clinical observations, we have carried out several batches of intermediate trials in the past few years to find a convenient process for the direct preparation of quinoline hydrochloride from total alkaloids. The process is shown in the attached table and the yield is about 0.03%. Galanthamine and haemanthidine were obtained from the alkaloid mother liquor. Beta-sitosterol was obtained in ethanol extract.