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目的探讨左炔诺孕酮宫内缓释系统(LNG-IUS)对预防子宫内膜息肉术后复发的疗效。方法 92例子宫内膜息肉术后患者作为研究对象,随机分为观察组及对照组,各46例。观察组患者术后予以左炔诺孕酮宫内缓释系统治疗,对照组患者术后不予以处理。比较两组患者术后随访6、12、18个月子宫内膜的厚度、息肉复发及不良反应发生情况。结果观察组患者术后随访6、12、18个月的子宫内膜厚度均薄于对照组,差异均具有统计学意义(t=20.955、103.547、263.416,P<0.05)。术后18个月,观察组患者子宫内膜息肉复发率为2.17%,低于对照组的13.04%,差异具有统计学意义(P<0.05)。观察组不良反应发生率为17.39%,对照组为13.04%,对比差异无统计学意义(χ~2=0.337,P>0.05)。结论临床运用左炔诺孕酮宫内缓释系统预防子宫内膜息肉术后复发能取得明显的疗效,能明显降低子宫内膜厚度,值得临床上推广和应用。
Objective To investigate the efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in preventing postoperative recurrence of endometrial polyps. Methods A total of 92 patients with endometrial polyps after surgery were randomly divided into observation group and control group, with 46 cases in each. Patients in the observation group were treated with levonorgestrel intrauterine system after operation, and patients in the control group were not treated after operation. The thickness of endometrium, the recurrence of polyps and the incidence of adverse reactions were compared between the two groups after 6, 12 and 18 months of follow-up. Results The thickness of endometrium in observation group was significantly lower than that in control group at 6, 12 and 18 months after operation (t = 20.955,103.547,263.416, P <0.05). At 18 months after operation, the recurrence rate of endometrial polyps in observation group was 2.17%, which was lower than that in control group (13.04%), the difference was statistically significant (P <0.05). The incidence of adverse reactions was 17.39% in the observation group and 13.04% in the control group, with no significant difference (χ ~ 2 = 0.337, P> 0.05). Conclusion The clinical application of levonorgestrel-releasing intrauterine system to prevent postoperative recurrence of endometrial polyps can achieve obvious curative effect, reduce the thickness of endometrium and deserve clinical application and promotion.