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黄连在祖国医学中应用甚早而广泛,1917年日本学者若林发现小蘖鹼封大腸桿菌、伤寒桿菌、及霍乱弧菌有抑制作用,1928年苏联学者发现植物殺菌素,此後即有许多学者研究植物的抗生物质,在祖国及日本等国亦有学者研究黄連浸膏及小蘖鹼的抗生作用,並碓定小蘖鹼为黄连主要抗生成份。但小蘖鹼对细菌抗生作用的机制則尚无报告,因此作者们从川产黄連中提取小蘖鹼,並作了若干种氨基酸、维生素和其他物质封小蘖鹼有无拮抗作用的研究,从而初步探讨其对金黄色葡萄球菌的抗生机制,此外,又研究了福氏痢疾桿菌,及溶血性链球菌对小蘖鹼的抗药性等。
Coptis used in the motherland medicine very early and widely used in 1917, the Japanese scholar Wolin found Berberine E. coli, Salmonella typhi, and Vibrio cholerae inhibitory effect, the Soviet Union scholars found that in 1928 phytoncide, since then there are many scholars Plant anti-biomass, also in the motherland and Japan and other countries also studied the antibacterial effect of Coptis chinensis and berberine extract, and Ding berberine is the main antibacterial ingredient of Coptis chinensis. However, the mechanism of antibacterial activity of berberine on bacteria is still unknown. Therefore, the authors extracted berberine from Chuanlian Coptis Chinensis and made some researches on the antagonism of several amino acids, vitamins and other substances, In order to preliminary study of its antibacterial mechanism of Staphylococcus aureus, in addition, also studied the Shigella flexneri, and hemolytic streptococcus resistance to berberine and so on.