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多年来的研究表明 ,白细胞介素 6 (ＩＬ 6 )可影响多种急性髓系白血病 (ＡＭＬ)细胞的生长与分化[1] ,现在知道 ,ＩＬ 6主要通过ＪＡＫ ＳＴＡＴｓ途径 (激活的核因子主要是ＳＴＡＴ3)和Ｒａｓ/ＭＡＰＫ/ＮＦ ＩＬ6途径将信号转导至核内[2 ] 。我们选择了多个ＡＭＬ细胞系 ,首
Over the years, studies have shown that interleukin 6 (IL 6) can affect the growth and differentiation of a variety of acute myeloid leukemia (AML) cells [1] and it is now known that IL 6 is mainly mediated by the JAK STATs pathway (activated nuclear factor mainly Is STAT3) and the Ras / MAPK / NF IL6 pathway transduces the signal into the nucleus [2]. We chose multiple AML cell lines first