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目的探讨糖尿病和冠心病与高同型半胱氨酸血症的关系。方法138例患者于冠状动脉造影前测定血浆Hcy及血脂、血糖等指标,将所有患者分为糖尿病合并冠心病组(33例)、单纯糖尿病组(19例)、单纯冠心病组(68例)和正常对照组(18例)4组,再根据冠状动脉造影将病变支数分为0、1、2和3支病变。结果糖尿病合并冠心病组及单纯冠心病组血浆Hcy水平较对照组比较均明显增高(P<0.01);糖尿病合并冠心病组血浆Hcy水平较单纯冠心病组和单纯糖尿病组Hcy水平均显著增高(P<0.01)。结论高同型半胱氨酸血症作为冠心病独立的危险因子,在预防和诊断糖尿病合并冠心病中具有重要的临床意义。
Objective To investigate the relationship between diabetes and coronary heart disease and hyperhomocysteinemia. Methods Thirteen patients with diabetes mellitus (CHD) group (n = 33), simple diabetic group (n = 19), simple coronary heart disease group (n = 68) And normal control group (18 cases). The lesions were divided into 0, 1, 2 and 3 lesions according to coronary angiography. Results The level of Hcy in diabetic patients with CHD and CHD group was significantly higher than that in control group (P <0.01). The plasma Hcy level in patients with diabetes mellitus and coronary heart disease was significantly higher than that in CHD group and simple diabetic group P <0.01). Conclusion Hyperhomocysteinemia is an independent risk factor for coronary heart disease, which has important clinical significance in preventing and diagnosing diabetes with coronary heart disease.