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维生素的生物利用度可以按照剂型中进入全身循环的维生素的相对量来计算。目前已广泛采用下列几种生化实验技术来评价其生物利用度:(a)血中营养物浓度的测定;(b)营养物尿排泄速率的测定;(c)营养物尿中代谢物的测定;(d)营养物血中成分以及与取样营养物有关的酶活性的变化;(e)负荷饱和度和同位素试验。尽管血、尿中营养物浓度的测定都会受到一些限制,但相对而言,血样测定较尿样方便。因为血样可为全血、血清和血浆,使研究
The bioavailability of vitamins can be calculated as the relative amount of vitamins entering the systemic circulation in the dosage form. The following biochemical laboratory techniques have been widely used to evaluate their bioavailability: (a) Determination of nutrient concentration in blood; (b) Determination of nutrient urinary excretion rate; (c) Determination of metabolites in urine of nutrients ; (d) Changes in composition of blood components of blood and the enzyme activity associated with sampled nutrients; (e) Load saturation and isotope test. Although blood and urine nutrient concentrations will be subject to some restrictions, but relatively speaking, the determination of blood samples more convenient than urine. Because the blood sample can be whole blood, serum and plasma, make the study