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目的 :观察地尔硫在高血压急性脑卒中病人中的降压作用。方法 :有急性脑卒中的高血压病人 6 5例 ,根据血压值不同 ,分为A组 31例 ,先采用地尔硫针剂 5 0mg溶于氯化钠注射液或 5 %葡萄糖注射液 2 5 0mL中 ,iv ,gtt ,2～ 4h滴完。 2 4h后 ,采用地尔硫缓释片剂 90mg ,po ,qd ,服用2wk。B组 34例 ,采用地尔硫缓释片剂 90mg ,po ,qd ,服用 2wk。结果 :A组和B组用药后d 14降压有效率分别为 90 %与 88% ,P >0 .0 5。A组病例静脉用药后 10 ,2 0 ,30 ,6 0 ,12 0min血压降压幅度与其前一观察时刻的血压值差别有显著意义 ,降压安全性达 90 %。 2组病例治疗后d 1,2 ,7,14的血压降压幅度与其前一观察值差别均有显著意义 ,治疗后d 7,14神经功能缺损评分和日常生活活动Barthel指数 ,与用药前比较差别均有显著意义。所有病例用药后不良反应轻微。结论 :地尔硫对高血压急性脑卒中病人的降压疗效确切、安全性高。
Objective: To observe the antihypertensive effect of diltiazem in patients with acute stroke of hypertension. Methods: Sixty-five hypertensive patients with acute stroke were divided into group A (n = 31) according to different blood pressure values. Fifty mg of diltiazem injection was first dissolved in sodium chloride injection or 5% glucose injection 0mL, iv, gtt, 2 ~ 4h drops finished. 2 4h, the use of diltiazem sustained release tablets 90mg, po, qd, taking 2wk. B group 34 cases, the Diltiazem sustained-release tablets 90mg, po, qd, taking 2wk. Results: The d 14 antihypertensive efficacies in group A and group B were 90% and 88%, respectively, P> 0.05. A group of patients intravenous medication after 10,20,03,06,0120min blood pressure amplitude range and the previous observation of the time difference between the blood pressure was significant, antihypertensive safety of 90%. There was significant difference between the two groups in the blood pressure-depressurization amplitude at d 1, 2, 7 and 14 and the previous observation after treatment. After treatment, the neurological deficit score at d 7,14 and the Barthel index of daily living activity were significantly different from those before treatment The difference is significant. Adverse reactions were mild in all cases. Conclusion: Diltiazem has an exact and safe antihypertensive effect on patients with acute stroke in hypertension.