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目的 :研究半边旗中二萜类化合物 5 F(11α-羟基 - 15 -氧 - 16 -烯 -对映贝壳杉烷 - 19酸 )对凝血酶诱导兔血小板聚集的影响。方法 :血小板悬液与 5 F孵育 1min,然后用凝血酶 (5 0 0 U/ L )作用 5 min,用血液凝集仪记录血小板聚集情况。结果 :半边旗中二萜类化合物 5 F对凝血酶诱导的兔血小板聚集有抑制作用。结论 :半边旗中二萜类化合物 5 F具有抗血小板的作用
Objective: To study the effect of diterpenoid 5 F (11α-hydroxy-15-oxa-16-ene-p-chorostane-19 acid) on thrombin-induced platelet aggregation in rabbits. Methods: The platelet suspension was incubated with 5 F for 1 min, and then treated with thrombin (500 U / L) for 5 min. The platelet aggregation was recorded by hemagglutination apparatus. Results: Diterpene 5 F in Pteris semipinnata inhibited the platelet aggregation induced by thrombin in rabbits. Conclusion: The diterpenoid 5 F in Pteris semipinnata has antiplatelet effect