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目的：研究外阴营养不良与性激素受体的关系。方法：采用直接荧光法，测定了１１例患者病变组织的性激素受体（ＳＨＲ）。其中增生型４例，硬化苔藓型４例，混合型３例。并对其中８例进行了外阴未发病组织ＳＨＲ对照。结果：（１）患者病变组织及未发病组织表皮各层及真皮层内均有不同程度的雌激素受体（ＥＲ）、孕激素受体（ＰＲ）、雄激素受体（ＡＲ）阳性率；（２）患者病变组织及未发病组织基底层ＥＲ、ＡＲ无或少于表皮其它各层（均为Ｐ＜０．０１）。结论：客观说明了外阴是性激素的靶器官之一，为临床应用丙酸睾丸酮能缓解硬化苔藓型患者临床症状提供了理论依据。而基底层ＳＨＲ缺少，推测这是应用性激素不能完全治愈本病的主要原因所在。
Objective: To study the relationship between vulvar dystrophy and sex hormone receptors. Methods: The sex hormone receptor (SHR) in diseased tissues of 11 patients was determined by direct fluorescence method. There were 4 cases of hyperplastic type, 4 cases of sclerosing moss type and 3 cases of mixed type. Eight of them were examined with SHR in vulvar non-diseased tissues. Results: (1) The positive rates of estrogen receptor (ER), progesterone receptor (PR) and androgen receptor (AR) in different degrees of epidermis and dermis in the diseased and non - (2) ER, AR in the diseased and non-diseased tissues were all lower than those in other layers of the epidermis (all P <0.01). Conclusion: Objectively illustrates that the vulva is one of the target organs of sex hormones and provides a theoretical basis for the clinical application of testosterone propionate to relieve the clinical symptoms of patients with sclerosing moss. The absence of basal SHR, presumably this is the main reason for the application of sex hormones can not completely cure the disease.