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报道昂丹司琼加地塞米松治疗以顺铂为主联合化疗引起的恶心、呕吐,并与甲氧氯普胺加地塞米松以及单用昂丹司琼三次进行对比研究。结果表明昂丹司琼加地塞米松止吐疗效可以达到91.9%~98.4%,单用昂丹司琼为78.0%~94.0%,而甲氧氯普胺加地塞米松仅为55.3%~85.3%。昂丹司琼加地塞米松及单用昂丹司琼的主要不良反应为便秘,发生率分别是12.9%、11.0%,未发生锥体外系副作用。
Reported ondansetron plus dexamethasone in combination with cisplatin-based chemotherapy induced nausea and vomiting, and metoclopramide plus dexamethasone and compared with three ondansetron alone. The results showed that ondansetron plus dexamethasone antiemetic efficacy can reach 91.9% to 98.4%, with only ondansetron 78.0% to 94.0%, and metoclopramide plus dexamethasone Only 55.3% ~ 85.3%. The main side effects of ondansetron plus dexamethasone and ondansetron alone were constipation, with rates of 12.9% and 11.0%, respectively, with no extrapyramidal side effects.