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目的 探讨T细胞接种 (TCV)对I型糖尿病的预防作用。方法 4周龄未发病的雌性NOD鼠用 18周龄新近发病的NOD鼠脾细胞制得的T细胞疫苗接种 ,检测TCV对NOD鼠糖尿病和胰岛炎的影响。结果 TCV可以降低糖尿病发病率及血糖平均水平 ,减轻胰岛单个核细胞的浸泡程度。结论 TCV可以诱导宿主产生自身免疫低反应性
Objective To investigate the preventive effect of T cell vaccination on type I diabetes mellitus (T2DM). Methods Four-week-old female NOD mice were vaccinated with T cells obtained from 18-week-old newly-infected NOD splenocytes to detect the effects of TCV on diabetic and insulitis in NOD mice. Results TCV can reduce the incidence of diabetes and blood glucose levels, reduce the degree of soaking of islet mononuclear cells. Conclusion TCV can induce the host to produce autoimmune hyporesponsiveness