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长期用高剂量皮质类留醇治疗多肌炎可产生严重毒副作用。作者报道10例患严重多肌炎的病人采用静注环磷酰胺成功地得到了治疗。 10例受试者均患严重的进行性肌炎,并均具有特征性活组织发现物或肌酶值升高。7例病人试验前使用皮质类留醇或与免疫抑制剂联合治疗;试验中同时使用留体激素和免疫抑制剂联合治疗。3例病人试验前未使用皮质类留醇治疗;试验中仅采用环磷酰胺治疗。试验中,环磷酰胺的治疗期一般为2～3个。所有病人在进入试验开始环磷酰胺治
Long-term use of high-dose corticosteroid alcohol treatment of polymyositis can have serious side effects. The authors report that 10 patients with severe polymyositis were successfully treated with intravenous cyclophosphamide. All 10 subjects had severe myophthalmos and all had characteristic features of a living tissue or elevated creatinine. Seven patients before trial use of cortical alcohol or immunosuppressive agents combined treatment; test using both hormone and immunosuppressive agents combined treatment. Three patients were not treated with cortical alcohol prior to the trial; only cyclophosphamide was used in the trial. Test, cyclophosphamide treatment period is generally 2 to 3 months. All patients started cyclophosphamide at the start of the trial