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向日葵非传统中药,但民间有用其茎芯煎剂治疗胃癌和肝病,无付作用。本实验以小白鼠移植性肉瘤180(S—180)为模型,探讨向日葵茎芯煎剂的抗肿瘤作用。实验分四批,每批实验和对照动物各10只,统计灌喂向日葵茎芯煎剂后肿瘤的消退率,並做肿瘤组织的光镜、电镜观察。实验前取小白鼠10只作药物毒性试验。按4.5克/公斤体重/日的剂量,连续灌喂向日葵茎芯煎剂20天,颈椎脱位处死动物,取心、肝、肺、肾作病理切片检查,均未见异常。灌喂过程中,小鼠精神良好,体重增加较快。
Sunflower is not a traditional Chinese medicine, but folk use its stem decoction for the treatment of gastric cancer and liver disease, no effect. In this study, the mouse transplanted sarcoma 180 (S-180) was used as a model to study the anti-tumor effect of sunflower stem decoction. The experiment was divided into four batches, each batch of 10 experimental animals and control animals. The rate of tumor regression after feeding sunflower stem decoction was counted, and the tumor tissues were observed under light and electron microscope. Before the experiment, 10 mice were taken for drug toxicity test. At the dosage of 4.5 g/kg body weight/day, sunflower stem decoction was continuously fed for 20 days. Animals were sacrificed by cervical dislocation, and heart, liver, lung, and kidney were used for pathological examination. No abnormality was observed. During the feeding process, the mice had good spirits and gained weight faster.