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目的探讨鞘内注射两性霉素B联合5-氟胞嘧啶治疗小儿细菌性脑膜炎的临床效果。方法随机选取2011年3月至2014年5月细菌性脑膜炎患儿60例,其中30例行静脉滴注两性霉素B和5-氟胞嘧啶为对照组,另30例行鞘内注射两性霉素B联合5-氟胞嘧啶为观察组,比较两组患者的治疗效果。结果对照组住院时间、白细胞恢复正常时间及体温恢复正常时间均长于观察组,差异有统计学意义(P<0.05)。对照组总有效率为50.0%,观察组为96.7%,两组比较差异有统计学意义(P<0.05)。结论对细菌性脑膜炎患儿鞘内注射两性霉素B联合5-氟胞嘧啶治疗效果良好,小儿的机体恢复快速,可临床推广应用。
Objective To investigate the clinical effects of intrathecal injection of amphotericin B combined with 5-fluorocytosine in the treatment of bacterial bacterial meningitis in children. Methods Sixty children with bacterial meningitis were randomly selected from March 2011 to May 2014, of which 30 were treated with intravenous amphotericin B and 5-fluorocytosine as control group, and the other 30 were given intrathecal injection of amphotericin In combination with 5-fluorocytosine in the observation group, the treatment effect was compared between the two groups. Results The length of hospital stay, the time to normal white blood cell recovery and the time to normal body temperature recovery in the control group were longer than those in the observation group, with significant difference (P <0.05). The total effective rate was 50.0% in the control group and 96.7% in the observation group, with significant difference between the two groups (P <0.05). Conclusion In children with bacterial meningitis intrathecal injection of amphotericin B combined with 5-fluorocytosine treatment effect is good, rapid recovery of children’s body, which can be clinically applied.