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目的分析云南省大理学院附属医院万古霉素临床合理使用情况。方法回顾性分析医院2014年3月-2015年3月300例患者使用万古霉素的情况,分析万古霉素科室使用、致病菌、合理用药、临床疗效。结果300例患者中呼吸内科(23.67%)及ICU(21.33%)万古霉素使用率较高;给药剂量以2g/d(63.67%)为主,给药途径以静脉滴注(95.33%)为主,用药疗程以7~14d(48.34%)为主,单一用药者(72.77%);革兰阳性细菌48.33%、阴性细菌为32.00%;合理用药为30.00%,基本合理用药为57.67%,不合理用药为12.35%;经验治疗有效率为69.49%,目标治疗有效率为99.17%。结论医院万古霉素的使用情况基本合理,加强标本送检,及时调整给药方案,缩短万古霉素经验性运用时间,快速控制感染是减少不合理运用万古霉素的有效方式。
Objective To analyze the clinical use of vancomycin in the affiliated hospital of Dali University, Yunnan Province. Methods A retrospective analysis of 300 cases of vancomycin in the hospital from March 2014 to March 2015 was carried out to analyze the use of vancomycin in departments, pathogens, rational use of drugs and clinical efficacy. Results The use of respiratory tract (23.67%) and ICU (21.33%) vancomycin was higher in 300 patients. The dosage was 2g / d (63.67%). The route of administration was intravenous drip (95.33% (48.33%) were single drug use (72.77%); Gram-positive bacteria was 48.33%, negative bacteria was 32.00%; Rational drug use was 30.00%, the basic rational drug use was 57.67% Irrational drug use was 12.35%; empirical treatment efficiency was 69.49%, the target treatment effective rate was 99.17%. Conclusions The use of vancomycin in hospitals is basically reasonable. It is an effective way to reduce the unreasonable use of vancomycin by strengthening the submission of specimens, timely adjusting the dosage regimen, shortening the empirical application time of vancomycin, and rapidly controlling infection.