1933年瑞典眼科医生Sjogren报告了原因不明的干燥性角膜炎及口内干燥的患者,大部分合并有类风湿,此后就称此病为Sjogren综合征(以下简称SS)。所谓SS疾患的最早记载是1882年由Leber报告的晚期角膜病变。1888年Mikulicz报告了继舌下与腮腺肿大引起泪腺肿大的病例,并详述了临床及病理学所见。1953年Mogan与Castleman研究了SS的唾液腺组织学特征。另外Hadden指出眼干常并发口干。1927年 In 1933, Swedish ophthalmologist Sjogren reported that in patients with unexplained dry keratitis and dry mouth, the majority of patients with rheumatoid arthritis were later referred to as Sjogren syndrome (hereinafter referred to as SS). The earliest record of so-called SS disease is the late corneal disease reported by Leber in 1882. In 1888 Mikulicz reported the cases of swelling of the lacrimal gland following sublingual and parotid gland enlargement and details of the clinical and pathological findings. 1953 Mogan and Castleman studied the salivary gland histological features of SS. In addition Hadden pointed out dry eye often dry mouth. 1927