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研究背景及临床问题:2型糖尿病的治疗药物众多,包括二甲双胍、胰岛素、磺脲类药物、噻唑烷二酮类药物、DPP-4抑制剂、SGLT-2抑制剂、GLP-1受体激动剂、非磺酰脲类胰岛素促分泌剂以及α-糖苷酶抑制剂、尽管上述药物在世界范围内广泛应用,但各种降糖药物治疗方案的临床结局对比结果尚不明确,尤其是死亡率和心血管事件。而
Research Background and Clinical Problems: Type 2 diabetes has a variety of therapeutic agents including metformin, insulin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors, SGLT-2 inhibitors, GLP-1 receptor agonists , Non-sulfonylurea insulin secretagogues and α-glucosidase inhibitors. Although these drugs are widely used in the world, the clinical outcome of various antidiabetic drug treatment regimens is still unclear. In particular, mortality and Cardiovascular events. and