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丹那唑作用机制至今尚未统一。过去认为主要作用为抗促性腺激素。后来发现接受丹那唑治疗妇女血中雌二醇(E_2)水平下降至绝经期或早期滤泡期水平。试管内试验证明参与卵巢组织内生成类固醇过程的一些酶受到抑制,认为丹那唑可能直接作用于卵巢。为了进一步澄清其作用部位,作者检验了对单次大剂量丹那唑的促性腺激素急性反应及治疗6个月期间促性腺激素基础水平以评价对下丘脑一垂体功能的潜在影响。也观察了丹那唑治疗妇女促性腺激素的基础水平和促性腺激素刺激的类固醇反应,估计药物可能直接作用于卵巢。选25例年龄在20～40岁,用药前月经规律妇女。5例患子宫内膜异位症,于月经第2、3、4
The mechanism of danazol has not been unified yet. In the past that the main role of anti-gonadotropin. It was later discovered that the level of estradiol (E2) in the blood of the women receiving danazol decreased to the level of menopausal or early follicular phase. In vitro tests showed that some enzymes involved in the process of steroidogenesis in ovarian tissue were inhibited, suggesting that it may act directly on the ovary. To further clarify the site of action, the authors examined the acute effects of a single high-dose Danazol on gonadotropins and the underlying levels of gonadotropin treatment over a six-month period to evaluate the potential impact on hypothalamic-pituitary function. The basal levels of danazol in women treated with gonadotropin and the steroid response stimulated by gonadotropin were also observed and it is estimated that the drug may act directly on the ovary. 25 cases of age 20 to 40 years old, regular menstruation before treatment. 5 cases of endometriosis, menstrual 2,3,4