论文部分内容阅读
目的探讨上消化道出血采用不同剂量奥美拉唑治疗的临床效果。方法选取2015年7月至2017年4月于辽阳石化总医院就诊的上消化道出血患者96例,按随机数字表法将其分为对照组与观察组,各48例。两组患者均以奥美拉唑治疗,对照组奥美拉唑给药剂量为每日40 mg,观察组奥美拉唑给药剂量为每日80 mg,比较两组患者的临床效果。结果观察组患者治疗总有效率为91.7%、止血时间(34±6)h与对照组的60.4%、(56±16)h比较,差异有统计学意义(P<0.05);治疗后,观察组患者心率明显低于对照组,收缩压、血红蛋白、血肌酐均显著高于对照组,差异均有统计学意义(均P<0.05)。结论在以奥美拉唑对上消化道出血治疗时,采取大剂量给药(每日80 mg)的方式能提高治疗效果,且不会导致不良反应风险增加。
Objective To investigate the clinical effects of omeprazole in different doses of upper gastrointestinal bleeding. Methods A total of 96 cases of upper gastrointestinal bleeding from July 2015 to April 2017 in Liaoyang Petrochemical General Hospital were enrolled and divided into control group and observation group according to random number table method, 48 cases each. The two groups were treated with omeprazole, the control group omeprazole daily dose of 40 mg, the observation group omeprazole dose of 80 mg daily, the clinical effect of two groups were compared. Results The total effective rate was 91.7% in the observation group and 34 ± 6 h in the control group compared with 60.4% in the control group and 56 ± 16 h in the control group (P <0.05). After treatment, Group heart rate was significantly lower than the control group, systolic blood pressure, hemoglobin, serum creatinine were significantly higher than the control group, the difference was statistically significant (P <0.05). Conclusions When omeprazole is used in the treatment of upper gastrointestinal bleeding, high-dose (80 mg daily) treatment improves the outcome without increasing the risk of adverse reactions.