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目的分析胸腔积液患者胸液中白细胞介素6(IL6)、C反应蛋白(CRP)水平,探讨两指标及其联合检测在胸腔积液性质鉴别诊断中的价值。方法将87例不同病因的胸腔积液患者分成漏出液组、良性渗出组及恶性渗出液组,平行检测胸腔积液中IL6、CRP水平,并通过受试者工作特征曲线(ROC)进行评价。结果良性渗出液组IL6、CRP值明显高于漏出液和恶性渗出液组(均P<0.01);恶性渗出液组IL6、CRP值明显高于漏出液组(均P<0.01)。分别以95pg/ml与12.5mg/L作为IL6、CRP诊断渗出液与漏出液的临界值。诊断渗出液的灵敏度分别为95.2%、90.3%;特异性分别为92.0%、90.0%。两指标联检,诊断渗出液的敏感性为96.7%,特异性为100%。结论胸腔积液IL6、CRP检测及其联合检测对鉴别胸腔积液性质有一定的实用价值。
Objective To analyze the levels of interleukin 6 (IL 6) and C-reactive protein (CRP) in pleural effusion of patients with pleural effusion and to explore the value of the two indexes and their combined detection in the differential diagnosis of pleural effusion. Methods 87 patients with pleural effusion of different etiologies were divided into two groups: leaking liquid group, benign exudative group and malignant exudate group. IL6 and CRP levels in pleural effusion were detected in parallel and were determined by receiver operating characteristic curve (ROC) Evaluation. Results The levels of IL6 and CRP in benign exudate group were significantly higher than those in leakage and malignant exudate group (all P <0.01). The levels of IL6 and CRP in malignant exudate group were significantly higher than those in the leakage group (all P <0.01). Respectively 95pg / ml and 12.5mg / L as IL6, CRP diagnostic exudate and leakage of the critical value. The sensitivity of diagnostic exudate was 95.2% and 90.3% respectively, and the specificity was 92.0% and 90.0% respectively. Joint detection of two indicators, the diagnosis of exudate sensitivity was 96.7%, specificity of 100%. Conclusion Pleural effusion IL6, CRP detection and its combined detection of pleural effusion to identify the nature of a certain practical value.