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目的:观察从医院用75%酒精消毒剂中检出的解淀粉芽孢杆菌(Bacillus amyloliquefaciens)对正常小鼠的致炎作用。方法:将该株解淀粉芽孢杆菌分别经呼吸道、消化道及伤口途径感染正常昆明种小鼠,观察感染小鼠的一般情况,定期进行血液白细胞计数和细菌学检查,并行内脏组织的细菌学和组织病理学检查。结果:解淀粉芽孢杆菌感染可引起白细胞数量增多,细菌学检查在感染早期为阳性,组织学检查可见轻度炎症反应,呼吸道试验组小鼠生长速度落后于对照组。结论:该株解淀粉芽孢杆菌对感染小鼠具有一定的致炎作用,并减缓小鼠生长速度。
OBJECTIVE: To observe the inflammatory effects of Bacillus amyloliquefaciens against 75% alcohol disinfectant in hospitals in normal mice. Methods: Normal Kunming mice were infected with Bacillus amyloliquefaciens via respiratory tract, digestive tract and wound respectively. The general situation of infected mice was observed. Blood leucocyte count and bacteriological examination were performed on a regular basis. Bacteriological and Histopathological examination. Results: Bacillus amyloliquefaciens infection could cause an increase in the number of white blood cells. Bacteriological examination was positive in the early stage of infection. Histological examination showed mild inflammatory reaction. The growth rate of mice in the respiratory tract experimental group lagged behind that in the control group. Conclusion: The strain Bacillus amyloliquefaciens has a certain degree of proinflammatory effect on infected mice and slows down the growth of mice.