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目的了解六个县0～15岁人群柯萨奇病毒A组16型(Coxsackievirus Group A Type16,CVA16)中和抗体(Neutralizing Antibody,NA)水平。方法选取广西壮族自治区和江苏省的3个手足口病(Hand,Foot and MouthDisease,HFMD)高发县和3个HFMD低发县作为研究现场,在每个县选取一个HFMD高发乡和一个HFMD低发乡,对调查现场的0～15岁人群及新生儿母亲采集静脉血标本,并对他们(或其家长)进行问卷调查。结果 <1岁各月龄组调查对象的CVA16血清NA阳性率随年龄的增长而下降;≥1岁各年龄组NA阳性率逐渐上升,其中6～10岁的CVA16NA阳性率最高。不同年龄、不同县调查对象CVA_(16)NA的阳性率差异均有统计学意义,但男、女性CVA_(16)NA的阳性率差异无统计学意义。0～15岁人群的CVA_(16)NA几何平均滴度(Geometric Mean Titer,GMT)为1∶8.44,<1岁各月龄和1岁的NA GMT均<1∶10,>1岁各年龄组NA的GMT上升,最高至1∶22.97。各县及不同性别的分年龄组NA GMT曲线与总NA的GMT曲线相似。结论六个县调查对象的CVA_(16)NA阳性率及GMT均较低,该六县0～15岁人群有发生CVA_(16)引起的HFMD爆发的风险。
Objective To understand the levels of Coxsackievirus Group A Type 16 (CVA16) Neutralizing Antibody (NA) in 0-15-year-olds in six counties. Methods Three high incidence HFMD and high incidence HFMD counties in Guangxi Zhuang Autonomous Region and Jiangsu Province were selected as research sites. One HFMD high incidence area and one HFMD low incidence area were selected in each county. Township, venous blood samples were collected from 0 to 15-year-olds and mothers of newborns at the survey site, and questionnaires were conducted among them (or their parents). Results The positive rate of NAA of CVA16 in each age group <1 year old decreased with the increase of age. The positive rate of NA in each age group of 1 year old increased gradually, and the positive rate of CVA16NA in 6 ~ 10 years old was the highest. The positive rates of CVA_ (16) NA in subjects of different ages and in different counties were all statistically significant, but there was no significant difference in the positive rate of CVA_ (16) NA between men and women. The geometric Mean Titer (CVT) of the CVA (16) NA in the age group of 0-15 years old was 1: 8.44, and the NA GMT of each age <1 year old and 1 year old were <1:10,> 1 year old Group NA’s GMT rose, up to 1:22.97. The NA GMT curve for each age group by county and by gender is similar to the GMT curve for total NA. Conclusions The positive rates of CVA (16) NA and GMT in all the six counties are low, and the risk of HFMD caused by CVA (16) in 0-15-year-old population of these six counties is high.