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目的探讨胃癌的雌、孕激素受体状况与预后关系。方法对３４例胃癌根治术后的标本以免疫组化（ＡＢＣ法）作ＥＲ、ＰＲ测定，并作５ａ随访。结果ＥＲ、ＰＲ阳性率皆为４１．２％（１４／３４）。高分化胃癌ＥＲ、ＰＲ阳性率（２６．９％）明显低于分化差的胃癌组（８７．５％）。随访５ａ，存活者中原来标记的ＥＲ、ＰＲ阳性率较低，仅为２０％。结论胃癌根治术后除辅以化疗外，ＥＲ、ＰＲ阳性者加内分泌治疗可能会提高５ａ生存率。
Objective To investigate the relationship between estrogen and progesterone receptor status and prognosis in gastric cancer. Methods 34 cases of radical resection of gastric cancer specimens by immunohistochemistry (ABC method) for ER, PR determination, and for follow-up 5a. Results The positive rates of ER and PR were all 41.2% (14/34). The positive rate of ER and PR in well-differentiated gastric cancer (26.9%) was significantly lower than that in poorly differentiated gastric cancer (87.5%). Follow-up 5a, the original marker of survivors ER, PR positive rate was low, only 20%. Conclusion In addition to chemotherapy after radical resection of gastric cancer, ER, PR-positive endocrine therapy may increase 5a survival rate.