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随机选择８例哮喘患者雾化吸入人重组ＩＬ－５，分别吸入前、吸入后２ｈ、２４ｈ和４８ｈ进行外周血有核细胞计数和分类，以放射免疫法测定血清中嗜酸性阳离子蛋白（ＥＣＰ）及总ＩｇＥ水平。结果，吸入ＩＬ－５后嗜酸性粒细胞（ＥＯＳ）占细胞总数的百分比、ＥＯＳ绝对细胞数以及ＥＣＰ水平均随时间而明显升高，至２４ｈ达最高值，４８ｈ后仍维持在较高水平；ＩＬ－５在整个实验过程中对血清总ＩｇＥ水平无明显影响。表明，吸入ＩＬ－５不仅可以促使循环中ＥＯＳ数明显增多，且还能招致其活化从而参与哮喘的发病过程。
Eight patients with asthma were randomly selected to inhale recombinant human interleukin-5 (IL-5). Peripheral blood mononuclear cells were counted and classified before inhalation, 2h, 24h and 48h after inhalation respectively. Serum eosinophilic cationic protein (ECP) And total IgE levels. As a result, the percentage of eosinophils (EOS) in the total number of cells, the absolute number of EOS and the level of ECP significantly increased with time after inhalation of IL-5, reaching the highest level at 24 h and remained at a relatively high level after 48 h. IL-5 had no significant effect on total serum IgE level throughout the experiment. It shows that inhaled IL-5 not only can promote the number of circulating EOS significantly increased, but also lead to its activation and thus participate in the pathogenesis of asthma.