环核苷酸是近廿年来生物化学的重要进展之一,1957年研究肾上腺素和胰高血糖素的机理时发现环磷酸腺苷(cAMP),1963年Ashman又检出了环磷酸鸟苷(cGMP).嗣后人们对环核苷酸的基本性质、生物作用、环核苷酸细胞内浓度的调节因素以及cAMp与cGMP的关系作了大量研究,对环核苷酸的生化、生理及药理作用有了进一步了 Cyclic nucleotides are one of the major advances in biochemistry in recent twenty years. Cyclic cAMP was found in the mechanism of the study of epinephrine and glucagon in 1957, and in 1963 Ashman again detected guanosine monophosphate cGMP) .Subsequently people have a lot of research on the basic properties of cyclic nucleotides, biological effects, regulatory factors of intracellular nucleotide concentration and the relationship between cAMp and cGMP, on the biochemical, physiological and pharmacological effects of cyclic nucleotides Got further