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目的 探讨运动康复对脑梗死大鼠学习记忆能力和习得性LTP的影响。方法 采用脑梗死动物模型 ,应用慢性埋植电极技术以电生理结合行为的方法 ,记录康复训练组和模型组大鼠Y 迷宫分辨学习前、60次训练及学会后在海马CA3 区的突触效应及其行为习得。结果 给予行为训练的康复组大鼠海马CA3区突触效应的习得性LTP的形成速度明显快于不给予任何训练的模型组 (P <0 .0 5 ) ,相应的Y 迷宫分辨学习的习得也明显强于模型组 (P <0 .0 5 )。结论 康复训练可加快海马CA3 区习得性LTP的形成 ,提高学习效率
Objective To investigate the effects of exercise rehabilitation on learning and memory ability and learned LTP in rats with cerebral infarction. Methods The animal model of cerebral infarction was established. The electrophysiological and behavioral methods were used to record the synaptic effects in the hippocampal CA3 region before training and after 60 training sessions in the Y-maze before and after training in the rehabilitation training group and the model group And their behavior acquisition. Results The rate of formation of acquired LTP in the hippocampal CA3 area of the rehabilitation group was significantly higher than that of the untreated group (P <0.05), and the corresponding Y-maze learning Obviously stronger than the model group (P <0.05). Conclusion Rehabilitation training can accelerate the formation of learned LTP in hippocampal CA3 area and improve the learning efficiency