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1971年 Combes 等首次报道了乙型肝炎病毒(HBV)和肾小球疾病之间的关系。既往研究提示以膜性肾小球肾炎最常见,在酒精性和 HBV 引起肝硬化病人中可伴 IgA 肾病,但在无症状 HBV 携带者中则未见报道。本文报道10例 HBV 携带者的 IgA 肾病,并探讨 HBV 在 IgA 肾病中的可能致病作用。125例经肾活检免疫荧光诊断的 IgA 肾病,并对62例在肾活检时及前4个月作 HBV 携带状态的血清学检查,发现10例 IgA 肾病患者有乙型肝炎表面抗原(HBsAg)血症。其中肾脏发现镜下血尿5例,无症状蛋白尿3例;肾病综合征1例;慢性肾衰1例。患者均无黄疸,无输血、肝脏病或药物等病史,且肝功能正常。
1971 Combes for the first time reported the relationship between hepatitis B virus (HBV) and glomerular diseases. Previous studies have suggested that membranous glomerulonephritis is the most common, with IgA nephropathy in patients with alcoholic and HBV-induced cirrhosis, but not in asymptomatic HBV carriers. This article reports 10 cases of HBV carriers of IgA nephropathy and explore the possible role of HBV in IgA nephropathy. 125 cases of IgA nephropathy diagnosed by renal biopsy and 62 cases of serological examination of HBV carrying status at the time of renal biopsy and the first 4 months and found that 10 cases of IgA nephropathy patients with hepatitis B surface antigen (HBsAg) blood disease. Among them, 5 cases of microscopic hematuria were found in kidney, 3 cases of asymptomatic proteinuria, 1 case of nephrotic syndrome and 1 case of chronic renal failure. None of the patients had jaundice, no history of blood transfusion, liver disease or medication, and liver function was normal.