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目的探讨无创正压通气联合雾化吸入治疗重症支气管哮喘的临床疗效。方法选取新余市分宜县中医院2016年收治的重症支气管哮喘患者64例,随机将患者分为对照组与研究组,各32例。对照组患者予以常规治疗,研究组在对照组基础上给予无创正压通气联合雾化吸入治疗,比较两组患者临床疗效、呼吸频率、心率、血氧分压、血氧饱和度及气道炎性因子[白介素6(IL-6)、白介素10(IL-10)和肿瘤坏死因子α(TNF-α)]水平。结果研究组临床疗效优于对照组(P<0.05)。研究组患者呼吸频率、心率低于对照组,血氧分压、血氧饱和度高于对照组(P<0.05)。治疗前两组患者气道炎性因子水平比较,差异无统计学意义(P>0.05);治疗后研究组患者IL-6、TNF-α水平低于对照组,IL-10水平高于对照组(P<0.05)。结论无创正压通气联合雾化吸入治疗重症支气管哮喘的临床疗效确切,可有效改善患者临床症状。
Objective To investigate the clinical effects of noninvasive positive pressure ventilation combined with inhalation on severe bronchial asthma. Methods Sixty-four patients with severe bronchial asthma admitted by FYI Hospital of Xinyu City in 2016 were randomly divided into control group and study group, with 32 cases in each group. Patients in the control group were treated routinely. The study group was given noninvasive positive pressure ventilation combined with inhalation therapy on the basis of the control group. The clinical effects, respiratory rate, heart rate, partial pressure of oxygen, oxygen saturation and airway inflammation were compared between the two groups Sex factor [interleukin 6 (IL-6), interleukin 10 (IL-10) and tumor necrosis factor alpha (TNF-alpha)] levels. Results The clinical efficacy of the study group was better than that of the control group (P <0.05). The study group patients with respiratory rate, heart rate was lower than the control group, partial pressure of oxygen, oxygen saturation higher than the control group (P <0.05). The levels of IL-6 and TNF-α in the study group were lower than those in the control group after treatment, and the level of IL-10 in the study group was higher than that in the control group (P <0.05). Conclusion Noninvasive positive pressure ventilation combined with inhalation of asthma for the treatment of severe bronchial asthma clinical curative effect can effectively improve the clinical symptoms.