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目的探讨类风湿关节炎(RA)与肿瘤坏死因子受体Ⅱ196(TNFRⅡ 196)基因位点多态性的关联情况。方法检索已发表有关RA和TNFRⅡ 196基因位点多态性的文献进行Meta分析。结果有9篇文献入选,共纳入2140例RA患者(RA组)和1297例健康者(健康对照组)。综合分析显示RA与TNFRⅡ196位点等位基因及TG、GG基因型不存在关联,OR值、95%CI和P值分别为1.11,(0.91,1.34),P=0.32;1.38,(0.97,1.98),P=0.07;1.09,(0.93,1.27),P=0.31。家族性RA与TNFRⅡ 196位点等位基因及GG基因型存在关联,OR值、95%CI和P值分别为1.43,(1.11,1.86),P=0.006;2.68,(1.39,5.17),P=0.003;家族性RA与TNFRⅡ 196TG基因型不存在关联,OR=1.00,95%CI(0.71,1.39),P=0.98。散发性RA与TNFRⅡ 196位点等位基因及GG、TG基因型不存在关联,OR值、95%CI和P值分别为1.13,(0.89,1.44),P=0.32;1.44,(0.75,2.76),P=0.27;1.03,(0.76,1.39),P=0.86。结论 Meta分析显示TNFRⅡ 196基因位点多态性与RA患者不具有关联,TNFRⅡ 196位点等位基因及GG基因型可能与家族性RA患者存在关联,与散发性RA无相关性。
Objective To investigate the association between rheumatoid arthritis (RA) and tumor necrosis factor receptor Ⅱ 196 (TNFR Ⅱ 196) gene polymorphism. Methods Meta-analysis of published literature on polymorphisms of RA and TNFRⅡ196 loci was performed. Results Nine articles were included, and 2140 patients with RA (RA group) and 1297 healthy subjects (healthy control group) were enrolled. Comprehensive analysis showed that there was no association between RA and TNFRⅡ196 alleles and TG and GG genotypes. The OR values, 95% CI and P values were 1.11, 0.91 and 1.34 respectively (P = 0.32; 1.38, 0.97, 1.98 ), P = 0.07; 1.09, (0.93, 1.27), P = 0.31. The familial RA was associated with the TNFRⅡ196 allele and GG genotype. The odds ratio (OR), 95% CI and P value were 1.43, (1.11, 1.86), P = 0.006, 2.68, = 0.003; there was no association between familial RA and TNFRII 196TG genotypes, OR = 1.00, 95% CI (0.71, 1.39), P = 0.98. There was no association between sporadic RA and TNFRⅡ196 alleles and GG, TG genotypes, with OR values 95% CI and P values of 1.13, (0.89, 1.44), P = 0.32, 1.44, (0.75, 2.76 ), P = 0.27; 1.03, (0.76, 1.39), P = 0.86. Conclusions Meta-analysis shows that TNFRⅡ196 locus polymorphism is not associated with RA patients. TNFRⅡ196 allele and GG genotype may be associated with familial RA patients and has no correlation with sporadic RA.