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目的:观察己酮可可碱(pentoxifylline,PTX)对自由基损伤心肌的作用和机制。方法:采用外源性氧自由基灌注致大鼠心肌损伤,观察自由基注射前、后不同时间阶段的心功能及血清丙二醛、乳酸和肌酸激酶含量的改变。结果:氧自由基注射后5分,心肌+dp/dt_(max)/Ⅱ_p由用药前34±2.7s~(-1)降至19±6.8s~(-1)(P<0.01),1小时后仍无明显好转(P<0.05)。血清丙二醛、乳酸及肌酸激酶的含量均明显升高。PTX,PTX+吲哚美辛,超氧化物歧化酶+过氧化物酶组,大鼠心功能无抑制倾向,血液生化指标也无明显波动。结论:PTX可保护大鼠心肌免受氧自由基的损伤。其作用机制除了它的舒血管特性外,还与其降低氧自由基对心肌的损伤有关。
Objective: To observe the effect and mechanism of pentoxifylline (PTX) on myocardial injury induced by free radicals. Methods: Cardiac injury was induced by exogenous oxygen free radical in rats. The changes of cardiac function, serum MDA, LDL and CK were observed at different time points before and after free radical injection. Results: Myocardial + dp / dt max / Ⅱp decreased from 34 ± 2.7 s ~ (-1) to 19 ± 6.8 s ~ (-1) 5 min after oxygen free radical injection (P <0.01) After hours still no significant improvement (P <0.05). Serum malondialdehyde, lactate and creatine kinase were significantly increased. PTX, PTX + indomethacin, superoxide dismutase + peroxidase group, no inhibition of cardiac function in rats, no significant fluctuations in blood biochemical indicators. Conclusion: PTX can protect rat myocardium from oxygen free radical damage. Its mechanism of action in addition to its vasodilator properties, but also with its reduced oxygen free radicals on myocardial injury.