目的　研究ｐ５３ 、ｃｅｒｂ Ｂ２ 、ＰＣＮＡ 在宫颈恶性腺瘤中的表达及其诊断价值。方法　采用免疫组织化学方法，检测ｐ５３ 、ｃｅｒｂＢ２ 和ＰＣＮＡ 在宫颈恶性腺瘤中的表达。结果　ｐ５３ 、ｃｅｒｂＢ２ 和ＰＣＮＡ 在２１ 例子宫颈恶性腺瘤中的表达分别为４７ ．６ ％ 、４ ．７ ％ 和１００ ．０ ％ ，而３５ 例宫颈良性病变均呈阴性反应。宫颈恶性腺瘤和子宫颈腺癌的ｐ５３ 、ＰＣＮＡ 阳性率无明显差异。结论　检测ｐ５３ 、ＰＣＮＡ 有助于子宫颈恶性腺瘤的鉴别诊断。 Objective To study the expression of p53, cerb B2 and PCNA in cervical adenocarcinoma and its diagnostic value. Methods Immunohistochemistry was used to detect the expression of p53, cerbB2 and PCNA in cervical adenocarcinoma. Results The expression of p53, cerbB2 and PCNA in 21 cases of cervical malignant adenoma was 47. 6%, 4. 7% and 100. 0%, while 35 cases of benign cervical lesions were negative. The positive rate of p53 and PCNA in cervical adenocarcinoma and cervical adenocarcinoma had no significant difference. Conclusions Detection of p53 and PCNA contributes to the differential diagnosis of cervical malignant adenoma.