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目的通过研究不同产地、品种夏枯草药材的组成差异性,为全面评价夏枯草属药材质量提供参考依据。方法通过HPLC法测定来源于9个产地夏枯草属3种药材,夏枯草Prunella vulgaris L.,山菠菜P.asiatica Nakai,硬毛夏枯草P.hispidaBent中咖啡酸、迷迭香酸、芦丁、槲皮素的量,并计算分析各成分间的结构比。结果不同品种的夏枯草药材中咖啡酸、迷迭香酸、芦丁、槲皮素量及组成结构比存在着较大差别;同一品种不同产地的夏枯草药材其4种成分量及组成结构比也存在着较大差别。其中江西产夏枯草中咖啡酸、迷迭香酸、芦丁、槲皮素量均最高;安徽产夏枯草和江苏产山菠菜4种成分量及组成结构比较相似,分别为1.0∶14.7∶3.9∶1.0和1.0∶14.8∶4.0∶0.8。结论由于产地、品种的不同,夏枯草属药材成分的组成存在差异性;成分间的结构比可能是夏枯草药效差异的根本原因,可用于夏枯草属药材的质量控制。
OBJECTIVE: To study the compositional differences of Prunella medicinal materials in different areas of origin and provide a reference for the comprehensive evaluation of Prunella medicinal materials. Methods HPLC method was used to determine the content of caffeic acid, rosmarinic acid, rutin, matrine, prunella vulgaris L., P. asiatica Nakai, P.hispidaBent from nine areas of Prunella, Quercetin, and calculate the structural ratio between the various components. Results The contents of caffeic acid, rosmarinic acid, rutin, quercetin and their composition in the different varieties of Prunella vulgaris were quite different. The contents of four components and compositional ratio There is also a big difference. Among them, the contents of caffeic acid, rosmarinic acid, rutin and quercetin in Prunella vulgaris were the highest in Jiangxi Province. The contents of four components and the composition of Prunella vulgaris and Spinachraceae in Jiangsu Province were relatively similar, which were 1.0: 14.7: 3.9 : 1.0 and 1.0: 14.8: 4.0: 0.8. Conclusion The composition of medicinal materials of Prunella vulgaris is different due to different origins and varieties. The structural ratio among the constituents may be the fundamental reason for the difference in potency of Prunella vulgaris, which can be used for the quality control of Prunella medicinal materials.