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目的探讨阿司匹林联合氯吡格雷及溶栓治疗急性ST段抬高型心肌梗死的临床疗效。方法 2011年5月至2013年5月,长葛市卫校附属医院诊治的64例急性ST段抬高型心肌梗死患者,根据随机数字法将其分为对照组(溶栓治疗)和观察组(对照组基础上,加用阿司匹林、氯吡格雷),每组32例,观察和比较两组临床疗效和不良反应。结果与对照组相比,观察组复发率和复合终点的发生率均显著降低,差异有统计学意义(P<0.05),两组不良反应比较差异无统计学意义(P>0.05)。结论对于急性ST段抬高型心肌梗死患者,阿司匹林联合氯吡格雷及溶栓治疗的疗效显著,值得临床广泛推广。
Objective To investigate the clinical efficacy of aspirin combined with clopidogrel and thrombolysis in the treatment of acute ST-segment elevation myocardial infarction. Methods From May 2011 to May 2013, 64 patients with ST-segment elevation acute myocardial infarction (MI) diagnosed and treated in Changge Medical School Affiliated Hospital were divided into control group (thrombolytic therapy) and observation group Control group based on the addition of aspirin, clopidogrel), 32 cases in each group were observed and compared the clinical efficacy and adverse reactions. Results Compared with the control group, the recurrence rate and the incidence of the composite end point in the observation group were significantly decreased (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Aspirin combined with clopidogrel and thrombolytic therapy has significant therapeutic effect in patients with acute ST-segment elevation myocardial infarction, and is worthy of widespread clinical application.