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目的评价口服降糖药联合甘精胰岛素治疗2型糖尿病的临床疗效。方法选取2012年3月至2013年2月2型糖尿病患者34例,所有患者就诊前均已接受口服降糖药血糖控制治疗,治疗效果不理想。治疗时在口服降糖药基础上于睡前加用甘精胰岛素进行皮下注射治疗,对治疗前后患者体质量指数(BMI)、空腹血糖(FPG)、餐后2 h血糖(2 h PG)、空腹C肽(FCP)及餐后2 h C肽(2 h CP)、糖化血红蛋白(HbA1c)等指标变化情况与低血糖发生率进行观察对比。结果治疗后,患者FPG、2 h PG、HbA1c均相较于治疗前均显著降低,FCP、2 h CP均较治疗前大幅升高。结论口服降糖药联合甘精胰岛素治疗2型糖尿病具有显著疗效,且安全性较高,患者体质量未显著增加,值得在临床中推广。
Objective To evaluate the clinical efficacy of oral hypoglycemic agents combined with insulin glargine in the treatment of type 2 diabetes mellitus. Methods From March 2012 to February 2013, 34 patients with type 2 diabetes mellitus were selected. All patients underwent oral hypoglycemic treatment before treatment. The treatment effect was not satisfactory. On the basis of oral hypoglycemic agents, glargine was injected subcutaneously at bedtime for treatment. Body mass index (BMI), fasting blood glucose (FPG), 2 h postprandial blood glucose (2 h PG) Fasting C-peptide (FCP) and postprandial 2 h C-peptide (2 h CP), glycosylated hemoglobin (HbA1c) and other indicators were observed and compared the incidence of hypoglycemia. Results After treatment, FPG, 2 h PG, HbA1c in patients were significantly lower than before treatment, FCP, 2 h CP significantly increased compared with before treatment. Conclusion Oral hypoglycemic agents combined with insulin glargine treatment of type 2 diabetes has a significant effect, and high safety, the patient’s body mass did not significantly increase, it is worth promoting in the clinic.