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目的总结探讨卡培他滨联合三维适形放疗治疗老年中晚期食管癌的临床疗效。方法随机选择2010年6月至2012年6月期间通许县人民医院收治的60例老年中晚期食管癌患者,随机分为对照组和实验组,每组各30例。对照组采用三维适形放疗治疗,实验组在对照组治疗的基础上联合采用卡培他滨治疗,观察比较两组临床治疗效果以及不良反应情况。结果试验组30例,总有效率为86.67%,明显高于对照组有效率(66.67%),差异有统计学意义(P<0.05);两组在胃肠道反应、骨髓抑制以及放射性反应等不良反应情况比较,差异未见统计学意义(P>0.05)。结论卡培他滨联合三维适形放疗治疗老年中晚期食管癌治疗效果好,安全便捷,值得临床推广使用。
Objective To summarize the clinical efficacy of capecitabine combined with three-dimensional conformal radiotherapy in the treatment of advanced esophageal cancer in elderly patients. Methods Sixty elderly patients with advanced esophageal cancer who were admitted to Tongxu People’s Hospital from June 2010 to June 2012 were randomly divided into control group and experimental group with 30 cases in each group. The control group was treated with three-dimensional conformal radiotherapy. The experimental group was treated with capecitabine on the basis of the control group. The clinical effects and adverse reactions of the two groups were observed and compared. Results The total effective rate was 86.67% in the experimental group (86.67%), which was significantly higher than that in the control group (66.67%), the difference was statistically significant (P <0.05). The gastrointestinal reactions, bone marrow suppression and radioactive reactions Adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Capecitabine combined with three-dimensional conformal radiotherapy for elderly patients with advanced esophageal cancer treatment effect is good, safe and convenient, worthy of clinical promotion and use.