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目的:比较莫沙比利与西沙比利在治疗功能性消化不良的疗效及不良反应。方法:门诊功能性消化不良病人222例随机分莫沙比利组85例,西沙比利组79例,安慰剂组58例进行治疗并观察疗效和不良反应。结果:莫沙比利组总有效率85.9％,西沙比利组总有效率86.1％,安慰剂组总有效率36.2％,莫沙比利组总有效率与西沙比利组疗效差异无显著性(p>0.05),以上两组与安慰剂组相比均疗效差异显著(p<0.001),且观察到莫沙比利的不良反应少且轻微(p<0.05),结论:两药在治疗功能性消化不良均可取得满意疗效,莫沙比利的不良反应更少更轻。
Objective: To compare the efficacy and side effects of mosapride and cisapride in the treatment of functional dyspepsia. Methods: 222 outpatients with functional dyspepsia were randomly divided into 85 cases of mosapride, 79 of cisapride and 58 of placebo. Efficacy and adverse reactions were observed. Results: The total effective rate in mosapride group was 85.9%, the total effective rate in cisapride group was 86.1%, the total effective rate in placebo group was 36.2%, the total effective rate in mosapride group was not significantly different from that in cisapride group (p> 0.05). There was significant difference (p <0.001) between the above two groups and the placebo group, with less and less adverse reactions observed in mosapride (p <0.05). Conclusion: Functional dyspepsia can achieve satisfactory results, mosapride adverse reactions with less and less.