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在肯尼亚高原地区恶性疟常随季节的变化而呈季节性流行。恶性疟原虫肝细胞期抗原-1(LSA-1)是肝细胞期疟原虫表达在裂殖体表面的一个约200 kDa的多肽分子,其N端和C端非重复区编码的氨基酸残基数为14-24的多肽能诱生IL-10、TNF-α、IFN-γ和CTL的应答。研究表明,在流行区人群中,如其外周血单核细胞(PBMC)产生对LSA-1应答的细胞因子,则再感染率下降。该文报道该地区儿童和成人的细胞因子的季节性变化情况。
The prevalence of P. falciparum in the highlands of Kenya is seasonal with seasonal changes. Plasmodium falciparum hepatocyte antigen-1 (LSA-1) is a polypeptide molecule of approximately 200 kDa expressed on the surface of schizont during the hepatocyte stage. The number of amino acid residues encoded by N-terminal and C-terminal non-repetitive regions Polypeptides that are 14-24 can induce IL-10, TNF-α, IFN-γ and CTL responses. Studies have shown that there is a reduction in re-infection of cytokines that respond to LSA-1 in peripheral blood mononuclear cells (PBMCs) in endemic areas. This article reports the seasonal changes in cytokines in children and adults in the area.