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作者以往的研究建议在尼日利亚生产并常规使用乳鼠脑组织狂犬病疫苗,本研究进一步观察了降低抗狂犬病治疗费用的结果,即用5针初免程序替代7针程序.作者用法国Pasteur Vaccins药厂生产的乳鼠脑组织狂犬病疫苗和马抗狂犬病超免疫血清,对73名狂犬病病毒接触者按下列免疫程序进行接种.程序Ia,25人于0～4天连续皮下注射2.0ml疫苗,并在10、28和90天分别皮内注射0.2ml疫苗;程序?b,25人按上述程序免疫,但在第0天第1次免疫接种前于肌肉或伤口周围注射剂量为40IU/kg体重的抗狂犬病血清;程序Ⅱ,23名被认为无罹患狂犬病危险性者分别在0、
Previous studies by the authors recommended that rabies brain rabies vaccine be produced and routinely used in Nigeria and this study further looked into the effect of reducing the cost of anti-rabies treatment by replacing the 7-needle procedure with a 5-prong priming procedure.Pasteur Vaccins, France Twenty-three rabies virus-exposed contacts were vaccinated with the following immunization program: The rabies brain vaccine and horse anti-rabies hyperimmune serum from the neonatal rat were prepared according to the following schedule of immunization: Procedure Ia, 25 were injected subcutaneously with 2.0 ml of the vaccine on day 0 to 4, , 28 and 90 days were intradermally injected with 0.2 ml of vaccine; procedure b, 25 were immunized according to the procedure described above, but anti-rabies was injected at a dose of 40 IU / kg body weight around the muscle or wound prior to the first immunization on day 0 Serum; procedure II, 23 were considered as having no risk of rabies at 0,