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以黄芩、甘草、丹皮、桂枝四味中药组成抗敏合剂,临床试用证明对支气管哮喘、喘息型支气管炎有一定疗效,为此我们对抗敏合剂进行了药理研究。现报告结果如下: 方法与结果药物制备:黄芩、甘草、桂枝、丹皮各9克共煎,制成水提取物,其最终体积为60毫升,临用时再配成所需浓度。一、抗过敏作用: (一)对致敏豚鼠过敏性休克的保护作用: 豚鼠体重150～250克,卵蛋白致敏四周后,分为两组,给药组腹腔注射抗敏合剂2.5克/公斤,每天一次,连续五天,对照组给等量生理盐水;于末次给药后30分钟,置钟罩内用10%新鲜鸡蛋清进行气雾攻击,以首次痉挛性腹式呼吸出现的时间(即惊
Astragalus, licorice, paeonol, cassia twig four herbs combined anti-allergic agent, clinical trials proved to have a certain effect on bronchial asthma, asthmatic bronchitis, for which we conducted a pharmacological study of antagonistic sensitizer. The results reported are as follows: Method and Results Drug Preparation: 9 grams each of Astragalus membranaceus, Radix Glycyrrhizae, Glycyrrhiza uralensis Fisch, and Dan Sage are co-fried to prepare a water extract with a final volume of 60 ml. First, anti-allergic effects: (A) of sensitized guinea pigs anaphylactic shock protection: guinea pigs weighing 150 to 250 grams, four weeks after the sensitization of ovalbumin, are divided into two groups, the administration group intraperitoneal injection of anti-allergic mixture 2.5 g/ Kg, once daily, for five consecutive days, the control group was given the same amount of saline; 30 minutes after the last administration, the aerosol was attacked with 10% fresh egg in the bell jar, and the time when the first abdominal respiration occurred (that is,